![]() ![]() One review theme emphasizes CP’s preponderant role in initiating central diseases, and their remediation. Agents/systems that counter oxidative activity such as matrix metalloproteinase 8 inhibitors and Nrf2 activators (bile acids and isothiocyanates) show promise as neural and CP protectants. Transducing LPS- and toll-like receptor activity produce CP-CSF cytokines in sickness behavior and virulent sepsis-associated encephalopathy. Lipopolysaccharide (LPS) is analyzed as a barrier-damaging agent and neuroinflammation promoter. This review highlights microbial agents, substrates and autoantigens using CP epithelial membranes to penetrate CSF and periventricular regions. BCSFB tight junctions and transcellular mechanisms differ from blood-brain barrier (BBB) counterparts, variably regulating pathogen and leukocyte access to the CSF-brain nexus. Newly-discovered choroidal phenomena include integration of circadian clock signals, immune interaction with gut microbiotica, and expression of receptors to taste CSF composition. BCSFB diversely manages brain-spinal cord fluid environments, giving rise to a wide pathophysiology spectrum. CP executes neuroendocrine, excretory, and neuroimmune actions. The choroid plexus (CP) of the blood-cerebrospinal fluid barrier (BCSFB) impacts CSF homeostasis, brain diseases, and neuromedical translation. ![]() Johanson 2ġDepartment of Neurosurgery, Alpert Medical School at Brown University, Providence, RI, 02903 USAĢ408 Autumn Trail, Georgetown, TX 78626, USA Choroid Plexus Blood-CSF Barrier: Major Player in Brain Disease Modeling and NeuromedicineĬonrad E. ![]()
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